Effects of 2600 MHz Radiofrequency Radiation in Brain Tissue of Male Wistar Rats and Neuroprotective Effects of Melatonin

Abstract

Overview

The interest and debate surrounding the biological impacts of radiofrequency radiation (RFR) continue, impacted by variations in experimental design factors like frequency, power density, and exposure duration.

Findings

• In this study, male Wistar rats were either exposed to 2600 MHz RFR or treated with melatonin, with some groups receiving both treatments.
• Exposure specifics: RFR exposure was set at 30 days, 30 minutes per day for 5 days a week, resulting in brain grey matter specific absorption rates (SAR) of 0.44 W/kg (1 g averaging) and 0.295 W/kg (10 g averaging).
• Biochemical and histological changes included decreased antioxidants like GSH, GSH-Px, and SOD, increased oxidative stress markers MPO, MDA, and NOx, and noticeable structural deformations and apoptosis in brain tissue.

Conclusion

Significant neuroprotective effects from high-dose melatonin were observed against RFR-induced damage. Limited exposure to RFR and daily intake of melatonin supplements could be beneficial for minimizing adverse effects.