Magnetic field-induced Ca 2+ intake by mesenchymal stem cells is mediated by intracellular Zn 2+ and accompanied by a Zn 2+ influx

Authors: Alp Özgün, Bora Garipcan

Year: 2021 May 22

Category: Molecular Cell Research

Journal: Biochim Biophys Acta Mol Cell Res

DOI: 10.1016/j.bbamcr.2021.119062

URL: https://pubmed.ncbi.nlm.nih.gov/34033861/

Abstract

Overview

Chronic exposure to magnetic fields (MFs) affects biological systems in diverse ways, yet the specific molecular mechanisms remain largely undefined.

Findings

  • Magnetic fields frequently increase the concentration of Ca2+ in cells through disputed pathways.
  • Other effects include enhanced oxidative stress and the upregulation of neural markers triggered by EGFR activation in stem cells.
  • The study reports both an influx of Zn2+ alongside MF-induced Ca2+ intake in bone marrow-derived mesenchymal stem cells, observed at 50 Hz MFs.
  • This effect is moderated by 2-Aminoethoxydiphenyl borate (2-APB) but not by other common blockers like memantine or ethosuximide.
  • Notably, when intracellular Zn2+ is chelated, cation influx is completely blocked, suggesting a critical role of Zn2+ in MF-induced effects.
  • The study dismisses voltage-gated Ca2+ channels as the cause for MF-induced Ca2+ intake, proposing instead a focus on Zn2+-related channels.

Conclusion

This study introduces new insights into the complex effects of magnetic fields on cellular mechanisms, indicating a significant role of Zn2+ in mediating these effects and suggesting potential health risks associated with chronic MF exposure.

magnetic fields mesenchymal stem cells Ca2+ intake Zn2+ influx oxidative stress
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