Alteration of testicular regulatory and functional molecules following long-time exposure to 900 MHz RFW emitted from BTS

Authors: Azimzadeh M, Jelodar G

Year: 2019 Jul 26

Category: Andrology

Journal: Andrologia

DOI: 10.1111/and.13372

URL: https://www.ncbi.nlm.nih.gov/pubmed/31347712

Abstract

Overview

The aim of the study was to analyze the impact of 900 MHz radiofrequency (RF) on key testicular regulatory and functional molecules in adult male Sprague Dawley rats.

Methodology

  • Population: Thirty adult male Sprague Dawley rats.
  • Groups: Three groups categorized as control, short-time exposure (STE, 2 hrs), and long-time exposure (LTE, 4 hrs).
  • Duration: 30 consecutive days of exposure.

Findings

  • Decrease in testosterone levels in exposed groups compared to control.
  • Increase in inflammatory markers like TNF-α in all exposed groups.
  • Significant elevation in IL-1α and nerve growth factor (NGF) levels specifically in the LTE group.
  • Expression of molecules like P450scc and StAR mRNA was significantly down-regulated in exposed groups.

Conclusion

Prolonged exposure to 900 MHz RF negatively affects testicular function by altering essential regulatory and functional molecules, impacting overall reproductive health.

RFW exposure testosterone decrease testicular function Leydig cells steroidogenesis inflammation
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