Oxidative stress response in SH-SY5Y cells exposed to short-term 1800 MHz radiofrequency radiation
Abstract
Overview
The study investigates the biological impacts of non-thermal radiofrequency (RF) radiation emission at 1800 MHz on human neuroblastoma cells (SH-SY5Y) focusing on the oxidative stress pathway.
Experimental Setup
- Frequency: 1800 MHz
- Exposure Duration: 10, 30, and 60 minutes
- Parameters: Electric field strength of 30 V m-1, Specific Absorption Rate (SAR) of 1.6 W kg-1
Findings
Several significant outcomes were observed:
- Cell viability remained stable post-exposure.
- Increase in reactive oxygen species (ROS) with all exposure durations.
- Significant oxidative damage to lipids and proteins post 60 minutes exposure.
- Highest antioxidant (GSH) concentration observed after 10 minutes of exposure.
Conclusion
The SH-SY5Y cells showed increased oxidative stress even with short-term exposure to RF radiation. The study highlights potential health risks associated with RF exposures and underscores the importance of further research into electromagnetic field radiation safety.