Oxidative stress response in SH-SY5Y cells exposed to short-term 1800 MHz radiofrequency radiation

Authors: Marjanovic Cermak AM, Pavicic I, Trosic I

Year: 2017 Nov 17

Category: Environmental Science and Health

Journal: J Environ Sci Health A Tox Hazard Subst Environ Eng

DOI: 10.1080/10934529.2017.1383124

URL: https://www.ncbi.nlm.nih.gov/pubmed/29148897

Abstract

Overview

The study investigates the biological impacts of non-thermal radiofrequency (RF) radiation emission at 1800 MHz on human neuroblastoma cells (SH-SY5Y) focusing on the oxidative stress pathway.

Experimental Setup

  • Frequency: 1800 MHz
  • Exposure Duration: 10, 30, and 60 minutes
  • Parameters: Electric field strength of 30 V m-1, Specific Absorption Rate (SAR) of 1.6 W kg-1

Findings

Several significant outcomes were observed:

  • Cell viability remained stable post-exposure.
  • Increase in reactive oxygen species (ROS) with all exposure durations.
  • Significant oxidative damage to lipids and proteins post 60 minutes exposure.
  • Highest antioxidant (GSH) concentration observed after 10 minutes of exposure.

Conclusion

The SH-SY5Y cells showed increased oxidative stress even with short-term exposure to RF radiation. The study highlights potential health risks associated with RF exposures and underscores the importance of further research into electromagnetic field radiation safety.

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