Rats exposed to 2.45 GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3

Abstract

Overview

This study investigates the effects of 2.45 GHz non-ionizing radiation, commonly used in Wi-Fi devices, on behavioral and oxidative stress parameters in female Sprague Dawley rats.

Methodology

Exposure to 2.45 GHz radiation was set at 4 hours per day for 45 days. Behavioral tests focusing on anxiety, learning, and memory started from day 38, while oxidative stress parameters were measured post-mortem on day 45.

Findings

• Behavioral tests showed declines in memory and increases in anxiety-like behavior in exposed rats.
• Decreases in antioxidant enzymes including superoxide dismutase and catalase were noted, alongside increased brain lipid peroxidation, indicating elevated oxidative stress.
• Gene expression analysis revealed increased levels of apoptotic marker caspase 3.
• Changes in neuronal dendritic structure were observed, suggesting alterations in neuron signaling.

Conclusion

The findings indicate significant detrimental effects of 2.45 GHz non-ionizing radiation on brain function and structure, aligning with other research on different EMF frequencies. Given the widespread use of Wi-Fi, these results underscore the potential risks to human health and emphasize the importance of further research into chronic exposures.