Association of Occupational Factors and Dementia or Cognitive Impairment: A Systematic Review and Meta- Analysis

Authors: Liang-Yu Huang, He-Ying Hu, Zuo-Teng Wang, Ya-Hui Ma, Qiang Dong, Lan Tan, Jin-Tai Yu

Year: 2020 Sep 19

Category: Epidemiology

Journal: J Alzheimers Dis

Institution: J Alzheimers Dis

DOI: 10.3233/JAD-200605

URL: https://pubmed.ncbi.nlm.nih.gov/32986670/

Abstract

Overview

This systematic review and meta-analysis investigates the influence of occupational factors on the risk of developing dementia and mild cognitive impairment (MCI).

Objective

The study aims to explore how modifiable occupational factors are associated with the risk of dementia or MCI.

Methods

  • Effective random-effect models were employed to analyze all occupational factors.
  • Subgroup analyses determined the effect of occupation type, complexity, and exposure on cognitive health.
  • Data was sourced from prospective cohort and case-control studies through PubMed and EMBASE up to March 2020.

Findings

  • Occupation type influencing mental work showed a 44% reduced risk of MCI.
  • High work complexity linked to a 5% reduced risk of dementia.
  • Significant findings revealed high strain and passive job roles in the longest-held job increased the risk of cognitive decline.
  • Notably, exposure to magnetic fields was associated with a 1.26-fold excess risk of dementia.

Conclusion

Development of novel prevention strategies focusing on occupational factors could be crucial in combating dementia and MCI.

occupational health dementia cognitive impairment meta-analysis occupational exposure
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