The Effects of Mobile Phone Radiofrequency Radiation on Cochlear Stria Marginal Cells in Sprague-Dawley Rats

Authors: Yang H, Zhang Y, Wang Z, Zhong S, Hu G, Zuo W

Year: 2020 Feb 18

Category: Bioelectromagnetics

Journal: Bioelectromagnetics

DOI: 10.1002/bem.22255

URL: https://www.ncbi.nlm.nih.gov/pubmed/32072661

Abstract

Overview

This study explores the biological effects of 1800 MHz mobile radiofrequency radiation (RFR) impacting cochlear stria marginal cells in rats. It focuses particularly on DNA damage, cell apoptosis, and reactive oxygen species (ROS) generation.

Findings

  • Radiation Exposure: Rats were exposed to RFR at absorption rates of 2 and 4 W/kg in a pattern mimicking conversation mode (5 minutes on, 10 minutes off).
  • Exposure Time: The duration of exposure was 24 hours.
  • Testing Methods: Post-exposure assessments included the Comet assay for DNA damage, flow cytometry, DAPI staining, and fluorescent probe for cell apoptosis and ROS detection.
  • Results: There was no significant DNA damage or increased apoptosis in the examined cells (P > 0.05). However, ROS production was significantly higher in the 4 W/kg exposure group compared to controls (P < 0.05).

Conclusion

Though short-term mobile RFR did not induce DNA damage or cell apoptosis in cochlear cells of Sprague-Dawley rats, it elevated ROS levels significantly in higher exposure groups, shedding light on the potential role of ROS activation in RFR's biological effects. The long-term cumulative effects of mobile phone radiation still warrant further investigation.

radiofrequency radiation ROS cell apoptosis DNA damage Sprague-Dawley rats
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