In vivo genotoxicity of high-intensity intermediate frequency magnetic fields in somatic cells and germ cells

Abstract

Overview

Intermediate frequency magnetic fields (IF-MFs) at ~85 kHz are integral to wireless power transfer (WPT) systems. Despite their widespread application, comprehensive safety data is lacking, especially concerning IF-MF's possible genotoxic effects.

Exposure System and Methodology

The study refines an existing system for intermittent animal exposure to high-intensity IF-MF at 3-second intervals. The system exposes mice to IF-MF at 82.3 kHz with an 87 V/m induced electric field, which is 3.8 times the restriction level for occupational exposure according to the ICNIRP guidelines, while controlling for heat generation caused by the coil.

Findings

• The study utilized the micronucleus (MN) test, Pig-a assay, and gpt assay to evaluate genotoxic effects.
• Exposure results in hematopoietic cells showed no significant increases in reticulocytes or mature erythrocytes in the IF-MF-exposed group compared to the sham-exposed group.
• No genetic or chromosomal abnormalities were detected in germ cells following IF-MF exposure.

Conclusion

This study concludes that high-intensity IF-MF exposure, as parameterized by the study, shows no genotoxic effects in both somatic and germ cells. These results reinforce the safety of IF-MF in WPT systems, supporting their safe deployment and operational use.