Exposure to 2.45 GHz Electromagnetic Radiation Induced Different Cell Responses in Neuron-like Cells and Peripheral Blood Mononuclear Cells

Abstract

Overview

The study discusses the risks associated with 2.45 GHz electromagnetic radiation emitted from common devices, emphasizing public health concerns due to DNA damage and central nervous system alterations.

Findings

• Examination of cell redox status alterations in human SH-SY5Y neuroblastoma cells and peripheral blood mononuclear cells under exposure.
• Key observations include significant decreases in cell viability, increased levels of reactive oxygen species (ROS), and mitochondrial dysfunction indicated by changes in mitochondrial transmembrane potential (ΔΨm), NAD+/NADH ratio, and mitochondrial transcription factor A (mtTFA).
• Evidence of stress response through expression changes in genes associated with apoptosis and autophagy such as BCL2, BAX, and LC3.

Conclusion

2.45 GHz EMR from widely used devices impacts cell functions, influencing ROS production and mitochondrial balance. These effects can vary depending on exposure time and cell type. Recommendations include limiting device use and further research to evaluate and mitigate these risks.