Electromagnetic Fields and Calcium Signaling by the Voltage Dependent Anion Channel

Abstract

Overview

Electromagnetic fields (EMFs) are known to interact with biological tissues, impacting cell viability positively and negatively. However, the specific sensing and signaling mechanisms behind these effects remain largely unexplored.

Findings

This study investigates how EMFs influence cells, focusing on the role of Calcium (Ca2+) influx via voltage-dependent anion channels (VDAC) in both excitable and non-excitable cells, such as erythrocytes. VDACs, initially found only in outer microsomal membranes, also transform to accommodate Ca2+ conducting capabilities in the cytoplasmic membrane due to subtle changes in EMF exposure. This ability of VDAC to convert and release Ca2+ into the cytosol highlights a potential targeted pathway by which EMFs can influence cellular activities.

Furthermore, the study examines the role of the 18 kDa translocator (TSPO), a protein associated with VDAC, which has structural similarities to magnetoreceptors and may sense the magnetic component of EMFs. This sensing capability of TSPO in conjunction with VDAC could initiate various physiological or pathological cell responses.

Conclusion

EMFs, particularly pulsed ones within brain-wave communication frequencies, could potentially cause psychic disturbances in susceptible individuals. The association between disruptions like insomnia, anxiety, and depressive states, and the influence of diazepines treatment suggests a significant link between EMF exposure and various psychological conditions.

These findings underscore the potential health risks associated with EMF exposure, emphasizing the importance of further investigating the mechanisms by which EMFs interact with biological systems.