Abstract

Overview

The development of new technologies and industry has led to an increase in the number and variety of electromagnetic field (EMF) sources, including high-voltage lines, household appliances, and mobile phones. The effects of EMF on human health, particularly in relation to cancerous cells, continue to be a significant area of scientific study.

Findings

• This study focused on the effects of extremely low frequency electromagnetic fields (ELF-EMF) on clear cell renal carcinoma, utilizing four in vitro cell lines: HEK293, 786-O, 769-P, and Caki1.
• Observed effects of ELF-EMF included slight reductions in cell viability, particularly notable in the 786-O line where early apoptotic cells increased and viable cell numbers decreased.
• ELF-EMF exposure led to increased levels of reactive oxygen species (ROS) across all tested cell lines soon after exposure.
• Significant inhibitory effects on migration, invasiveness, and metastatic properties of cancer cells were also observed.

Conclusion

The research highlights the potential inhibitory effects of ELF-EMF on the development and spread of primary cancer cells, ultimately affecting cell proliferation, migration, and survival. The outcomes vary depending on the specific metabolic state or cell cycle stage, indicating a nuanced interaction between EMF exposure and cellular behavior. These findings suggest a need for heightened awareness and further research into the health implications of everyday EMF exposure.