The effect of radiofrequency electromagnetic fields (RF-EMF) on biomarkers of oxidative stress in vivo and in vitro: A protocol for a systematic review

Abstract

Abstract Summary

Overview

Oxidative stress is suspected to be linked with several diseases and potentially exacerbated by the influence of radiofrequency electromagnetic fields (RF-EMF). This systematic review aims to critically aggregate and evaluate the existing research examining the connection between RF-EMF exposure and oxidative stress in various experimental models.

Objectives

The primary goal of this review is to assess the relationship between RF-EMF exposure and oxidative stress manifestations in both in vivo and in vitro settings.

Methods

• Adherence to WHO's guidelines for systematic review protocols.
• Inclusion of controlled laboratory studies assessing RF-EMF’s impact on oxidative stress markers against control setups.
• Extensive database search including PubMed and Scopus, among others.

Findings and Synthesis

Data will be extracted using DistillerSR and synthesized into a meta-analysis format whenever possible, or described narratively based on the study similarities.

Risk and certainty evaluation

Risk of bias will be analyzed using the NTP/OHAT tool, and the certainty of outcomes will be evaluated using the GRADE approach.

Conclusion

The systematic review is supported by WHO and registered under PROSPERO. Its findings are crucial in understanding the depth of RF-EMF's impact on health via oxidative stress, enhancing existing knowledge and possibly guiding public health policies.