The effect of radiofrequency electromagnetic fields (RF-EMF) on biomarkers of oxidative stress in vivo and in vitro: A protocol for a systematic review

Authors: Bernd Henschenmacher, Annette Bitsch, Tonia de las Heras Gala, Henry Jay Forman, Athanassios Fragoulis, Pietro Ghezzi, Rupert Kellner, Wolfgang Koch, Jens Kuhne, Dmitrij Sachno, Gernot Schmid, Katya Tsaioun, Jos Verbeek, Robert Wright

Year: 2022

Category: Health Sciences

Journal: Environment International

Institution: World Health Organization

DOI: 10.1016/j.envint.2021.106932

URL: https://www.sciencedirect.com/science/article/pii/S0160412021005572

Abstract

Abstract Summary

Background: Oxidative stress is linked to many diseases, and it's hypothesized that exposure to radiofrequency fields might induce oxidative stress in various cell types, potentially compromising health.

Overview

This systematic review aims to summarize and critically evaluate the literature assessing the potential health risks associated with RF-EMF exposure and its relation to oxidative stress in experimental models.

Objectives

The primary objective is to assess the connection between RF-EMF exposure and oxidative stress in in vivo and in vitro models.

Methods

  • Review guided by WHO and other relevant handbooks
  • Inclusion of controlled lab studies
  • Comprehensive database search and manual review of references
  • Data synthesis through meta-analysis or narrative description

Risk Assessment

Risk of bias evaluated using standard tools; Grading of evidence strength with GRADE.

Funding and Registration

Funded by WHO, protocol registered in PROSPERO.

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