Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo

Authors: Herrala M, Kumari K, Koivisto H, Luukkonen J, Tanila H, Naarala J, Juutilainen J

Year: 2018 Sep 8

Category: Environmental Health

Journal: Environ Res

DOI: 10.1016/j.envres.2018.09.009

URL: https://www.ncbi.nlm.nih.gov/pubmed/30243651

Abstract

Overview

We conducted a detailed study to assess the genotoxic effects of intermediate frequency magnetic fields (MF) on both cellular and animal models.

Methodology

  • Used rat primary astrocytes exposed for 24 hours to 7.5 kHz MF at 30 or 300 µT
  • Male C57BL/6 J mice exposed continuously for 5 weeks to 7.5 kHz MF at 12 or 120 μT
  • Included genotoxic assays on blood samples
  • Implemented combined exposure experiments with genotoxic agents menadione and methyl methanesulfonate

Findings

  • No support for genotoxicity or co-genotoxicity at specified intervals
  • Some evidence indicated a potential reduction in genetic damage
  • Significant increase in relative cell number post-exposure, suggesting possible stimulation of cell proliferation or suppression of cell death

Conclusion

While our findings do not directly indicate genotoxic effects, changes in cell proliferation rates highlight an area of potential concern, suggesting more research is needed into the health implications of 7.5 kHz MF exposure.

genotoxicity magnetic fields in vitro in vivo DNA damage cell proliferation environmental research
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