Exposure to a specific time-varying electromagnetic field inhibits cell proliferation via cAMP and ERK signaling in cancer cells

Authors: Buckner CA, Buckner AL, Koren SA, Persinger MA, Lafrenie RM

Year: 2017 Nov 10

Category: Bioelectromagnetics

Journal: Bioelectromagnetics

DOI: 10.1002/bem.22096

URL: https://www.ncbi.nlm.nih.gov/pubmed/29125193

Abstract

Overview

This study examines the effects of Thomas-EMF, a specially patterned low-intensity, frequency-modulated electromagnetic field (EMF), on various cancer cells. The research specifically explores how this EMF pattern impacts cell proliferation.

Findings

  • Exposure to Thomas-EMF for 1 hour per day inhibited the growth of multiple malignant cells, including B16-BL6 mouse melanoma cells and various human breast and cervical cancer cells.
  • The EMF pattern did not affect the growth of non-malignant cells, indicating specific action on cancerous cells only.
  • The inhibition of cell proliferation by Thomas-EMF was mediated through the cAMP and ERK signaling pathways.
  • Pharmacological modulation of these pathways altered the effects of Thomas-EMF on cancer cells, further supporting the mechanism of action.

Conclusion

This study underscores the potential of using specific EMF patterns to selectively inhibit cancer cell growth, highlighting the importance of further research into EMF effects on cellular biology.

EMF cell proliferation cancer cAMP signaling ERK signaling electromagnetic field health risk
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