The Protective Effects of EMF-LTE against DNA Double-Strand Break Damage In Vitro and In Vivo

Abstract

Overview

With the expansion of the wireless communication sector, there is a substantial increase in human exposure to electromagnetic fields (EMF), primarily in the form of radiofrequency (RF). The skin, being the outermost body layer, is deemed a significant target of these fields.

Findings

Recent studies have hinted at low-frequency EMFs' possible role in enhancing DNA repair mechanisms in human cell lines. Yet, the specific effects of long-term evolution (LTE) EMFs on DNA integrity were less understood. This research aimed to explore the impact of EMF-LTE (1.762 GHz, 8 W/kg) on DNA double-strand breaks (DSBs) within murine melanoma and human keratinocyte cell lines.

• EMF-LTE exposure did not compromise cell viability or trigger apoptotic or necrotic responses.
• The exposure was found to mitigate DNA DSB damage induced by various DNA-damaging agents like ionizing radiation and bleomycin in cell culture.
• It also reduced the markers of DNA damage in vivo after extended exposure in mice, suggesting a protective role against DNA damage in skin tissues.
• Additionally, an upregulation was observed in the p53 tumor-suppressor gene, implicating it in the protective effects against DNA DSBs conferred by EMF-LTE.

Conclusion

This study demonstrates a potential protective effect of EMF-LTE against DNA DSB damage, thereby perhaps moderating some of the health risks associated with EMF exposure. Further investigations are recommended to fully understand these effects on human health, emphasizing the importance of thorough EMF impact assessments.