Protective role of spermine against male reproductive aberrations induced by EMF exposure in the rat

Authors: Shahin NN, El-Nabarawy NA, Gouda AS, Megarbane B

Year: May, 2019

Category: Toxicology and Pharmacology

Journal: Toxicology and Applied Pharmacology

DOI: 10.1016/j.taap.2019.03.009

URL: https://www.sciencedirect.com/science/article/pii/S0041008X19300912

Abstract

Overview

The research addresses the significant health risks associated with the prevalent use of EMF-emitting devices, focusing on male fertility. It evaluates spermine's protective role against EMF-induced reproductive harms.

Findings

  • Exposure to EMF results in decreased sperm count, viability, and motility, increased sperm deformities, and hormonal imbalances.
  • Significant decreases were observed in testosterone levels and increases in follicle-stimulating hormone and estradiol concentrations.
  • The study reports EMF-induced oxidative, inflammatory, apoptotic, and DNA damage in rat testes. Spermine was found to mitigate these adverse effects significantly.

Conclusion

Spermine exhibits potent protective effects against EMF-induced disruptions in spermatogenesis and steroidogenesis, displaying antioxidative, anti-inflammatory, and anti-apoptotic properties.

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