Anxiety-like behavioural effects of ELF EMF in rats

Authors: Djordjevic NZ, Paunović MG, Peulić AS

Year: 2017 Jul 29

Category: Environmental Science, Neuroscience

Journal: Environ Sci Pollut Res Int

DOI: 10.1007/s11356-017-9710-1

URL: https://www.ncbi.nlm.nih.gov/pubmed/28756602

Abstract

Overview

Recent study focuses have highlighted concerns over the biological effects of extremely low-frequency electromagnetic fields (ELF-EMFs), especially their role in behaviour modulation. This study particularly investigates the short-term impacts of ELF-EMF exposure (50 Hz) on anxiety-like behaviour in rats, emphasizing changes in hypothalamic oxidative stress and nitric oxide (NO) levels.

Methodology & Findings

  • Subjects: Ten adult male Wistar albino rats were divided into two groups—control (no ELF-EMF exposure) and experimental (exposed to ELF-EMF for seven days).
  • Behavioral Tests: Anxiety-like behaviours were assessed using the open field test and the elevated plus maze following ELF-EMF exposure.
  • Biological Assessments: Post-test concentrations of superoxide anion (O2·-), nitrite (NO2−, an indicator of NO), and peroxynitrite (ONOO−) were measured in the rat's hypothalamus. Results indicated increased levels of O2·- and NO, with no significant change in ONOO− concentrations.

Conclusion

Exposure to ELF-EMF contributes to the development of anxiety-like behaviour in rats, mediated by increasing oxidative stress and NO levels in the hypothalamus. This finding underscores potential health risks associated with ELF-EMF exposure, suggesting a direct link to adverse behavioural outcomes.

ELF EMF rats anxiety behaviour oxidative stress electromagnetic fields health risks
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