Pulsed or continuous EMF induce apoptotic signaling pathway in mouse spermatogenic cells in vitro and may affect male fertility

Authors: Solek P, Majchrowicz L, Bloniarz D, Krotoszynska E, Koziorowski M

Year: 2017 Mar 16

Category: Toxicology

Journal: Toxicology

DOI: 10.1016/j.tox.2017.03.015

URL: https://www.ncbi.nlm.nih.gov/pubmed/28323003

Abstract

Overview

The impact of electromagnetic field (EMF) on human health and the environment has been a pressing issue, with increased concentration of EMF raising public concerns due to the potential long-term effects on living organisms.

Findings

  • The study examines the effects of pulsed and continuous EMF on mouse spermatogenic cell lines in vitro.
  • Focus areas included mitochondrial metabolism, morphology, cell proliferation, viability, cell cycle progression, and oxidative stress balance.
  • Results indicated significant oxidative and nitrosative stress-mediated DNA damage, leading to p53/p21-dependent cell cycle arrest and apoptosis.

Conclusion

EMF exposure in the surrounding environment significantly impairs male fertility through disruption of cellular processes in spermatogenic cells, resulting in reduced healthy sperm cells pool due to oxidative and nitrosative stress-mediated cytotoxic and genotoxic events. This emphasizes the risks associated with EMF exposure relevant to public health policy.

EMF male fertility apoptosis oxidative stress spermatogenic cells
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