Pulsed high-power microwaves do not impair the functions of skin normal and cancer cells in vitro: A short-term biological evaluation

Authors: Mumtaz S, Bhartiya P, Kaushik N, Adhikari M, Lamichhane P, Lee S-J, Kaushik NK, Choi EH

Year: Mar 2020

Category: Biological Research

Journal: J Advance Research

DOI: 10.1016/j.jare.2019.11.007

URL: https://doi.org/10.1016/j.jare.2019.11.007

Abstract

Overview

This study explores the effects of pulsed high-power microwaves (HPMs) on human skin cells, specifically melanoma cells and normal dermal fibroblasts. The use of microwave radiation in biology has raised interest due to its prevalent use and the need to understand its biological implications better.

Findings

  • A pulsed power generator called Chundoong was used, generating microwaves at a frequency of 3.5 GHz.
  • Despite delivering significant electromagnetic energy, the microwaves did not induce cell death, nor did they alter the morphology of the melanoma or fibroblast cells.
  • Distinct effects on cell viability and proliferation, particularly in melanoma cells, were observed, suggesting cell-type specific interactions.
  • The gene expression related to ATP synthesis and proliferation was altered, indicating microwave influence on cellular activities.

Conclusion

The study indicates a potential increase in mitigating risks and deeper cellular analysis when using microwave exposure, especially with melanoma cells. Mitotic inhibitory drugs in conjunction with microwave exposure are suggested for further research.

microwaves skin cells cancer cell viability electromagnetic fields
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