Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells

Authors: Patrignoni L, Hurtier A, Orlacchio R, Joushomme A, Poulletier de Gannes F, Lévêque P, Arnaud-Cormos D, Revzani HR, Mahfouf W, Garenne A, Percherancier Y, Lagroye I

Year: 2023 Dec 19

Category: Bioelectromagnetics

Journal: Bioelectromagnetics

DOI: 10.1002/bem.22495

URL: https://pubmed.ncbi.nlm.nih.gov/38115173/

Abstract

Overview

Concerns related to the impact of environmental electromagnetic fields, specifically from emerging 5G technologies, on human health persist. This study focuses on the impact of 5G-modulated 3.5 GHz signals on mitochondrial stress in skin cells.

Findings

A 24-hour exposure of human skin cells, including fibroblasts and keratinocytes, to 5G signals demonstrated varying effects on mitochondrial reactive oxygen species (ROS) production, depending on cell type and radiation dose.
In fibroblasts, there was a significant reduction in ROS at 1 W/kg. In contrast, keratinocytes showed an increase in ROS post UV-B exposure at doses of 0.25 and 1 W/kg.
These changes did not translate to effects on mitochondrial membrane potential or apoptosis, suggesting the response to RF-EMF is specific and limited.
To comprehensively judge the relevance of these findings to potential health risks, further investigations using three-dimensional skin models or in vivo approaches are proposed.

Conclusion

The study identifies selective alterations in mitochondrial function due to 5G RF-EMF exposure, which aids in understanding the subtle yet statistically significant biological effects. While no definitive health risks are confirmed, the findings signal potential areas for further research, particularly in the context of combined 5G and UV exposure, to evaluate any consequential health impacts.

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