Abstract

Abstract

Overview

Mobile communications, which have used pulse-modulated signals like the GSM-1800 MHz since the 1990s, are facilitated through electromagnetic fields (EMFs). The impact of GSM-EMF on humans with neuropathological conditions has been sparingly studied.

Findings

• A 2-hour single head exposure to GSM-1800 MHz was administered to three different groups of rats: those with acute neuroinflammation induced by lipopolysaccharide (LPS), healthy age-matched rats, and transgenic hSOD1G93A rats representing a presymptomatic phase of ALS.
• Gene responses were evaluated in the cerebral cortex's motor area 24 hours post-exposure, where specific absorption rates averaged 3.22 W/kg.
• In LPS-treated rats, genome-wide mRNA supervision using RNA-seq highlighted statistically significant yet mild modulation affecting 2.7% of expressed genes, involving key biological processes like protein ubiquitination and dephosphorylation.
• Specific gene response variations, confirmed by reverse transcription-quantitative PCR, were exclusive to the LPS-induced neuroinflammatory conditions, as they were absent in the healthy and ALS model rats.

Conclusion

The study underscores the selective vulnerability of the cortical transcriptome to GSM-1800 MHz signals during acute inflammatory states, portraying GSM-EMF’s potential differentiated impact based on underlying neurological conditions.