Effect of 1.8 GHz RF EMR on novel object associative recognition memory in mice

Authors: Wang K, Lu JM, Xing ZH, Zhao QR, Hu LQ, Xue L, Zhang J, Mei YA

Year: 2017 Mar 17

Category: Neuroscience

Journal: Sci Rep

DOI: 10.1038/srep44521

URL: https://www.ncbi.nlm.nih.gov/pubmed/28303965

Abstract

Overview

Research increasingly indicates that radiofrequency electromagnetic radiation (RF-EMR) may impact rodent learning and memory processes. This study specifically explores how a brief exposure influences recognition memory.

Methodology

The experiment involved a single 30-minute session of 1.8 GHz RF-EMR exposure at a power density of more than 2.2 W/kg specific absorption rate (SAR). The effects on memory were assessed using the novel object recognition task (NORT).

Findings

  • Density-dependent improvement in NORT index, suggesting enhanced memory recognition.
  • Dendritic spine density and length increases in hippocampal and prefrontal cortical neurons, implying structural neuronal changes.
  • RF-EMR exposure notably altered neuronal properties such as resting membrane potential and action potential frequency in neurons.

Conclusion

This study provides evidence that 1.8 GHz RF-EMR can enhance recognition memory in mice and influence neuronal morphology and excitability. Although the SAR used was higher than that in typical environmental exposures, these findings could have implications for medical therapeutic strategies targeting memory deficits.

RF-EMR recognition memory mice neuroscience dendritic-spine neuronal excitability
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