Abstract

Overview

The study explores the impact of 50 Hz and 60 Hz magnetic fields on oxidative stress and DNA responses in SH-SY5Y human neuroblastoma cells.

Purpose

The research aimed to analyze the effects of electromagnetic fields on various cellular mechanisms related to oxidative stress and DNA integrity.

Materials and Methods

• Cells were exposed to 100 µTRMS magnetic fields or were sham-exposed.
• Assessment included measuring reactive oxygen species and DNA damage post-exposure.

Findings

A slight increase in the activity of genes associated with antioxidant responses was observed, suggesting a subtle response to increased ROS levels. Notably, the exposure to 50 Hz fields resulted in a consistent reduction in menadione-induced ROS levels, whereas 60 Hz fields did not show a significant effect.

Further results indicated no substantial impact on DNA damage or its repair mechanisms.

Conclusion

Despite minimal effects observed, the findings align with potential influences of magnetic fields on cellular oxidative mechanisms. However, the implications for human health need further investigation given the subtle nature of the effects.