The role of melatonin in preventing ovarian tissue damage in rats exposed to magnetic fields

Authors: Küçük Z, Erkayıran U, Çaydere M, Kayaalp D, Karca Altıncaba D

Year: 2018 Oct 31

Category: Biomedical Research

Journal: Turk J Med Sci

DOI: 10.3906/sag-1707-98

URL: https://www.ncbi.nlm.nih.gov/pubmed/30384578

Abstract

Overview

This study examines the protective effects of melatonin on ovarian tissue in rats subjected to magnetic fields.

Materials and Methods

  • Four groups of rats, ten in each: Control, Melatonin only, Magnetic field only, and both treatments.
  • Magnetic field exposure was at 20 μT for 30 min/day over 10 days.
  • Melatonin administered orally at a dose of 10 mg/kg.
  • Assessments included follicle count, fibrosis, adhesions, apoptosis, ovarian dimensions, and follicular degeneration.

Findings

The group exposed only to magnetic fields showed higher rates of follicular degeneration, fibrosis, and adhesion, though these were not statistically significant compared to the group treated with melatonin. Apoptosis was significantly higher in the exposed groups compared to controls.

Conclusion

The study suggests that high doses of melatonin could be a non-toxic, anti-apoptotic agent that may help protect against ovarian tissue damage potentially caused by radiation.

melatonin ovarian tissue magnetic fields rats radiation protection apoptosis
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