The protective effects of melatonin against electromagnetic waves of cell phones in animal models: A systematic review

Authors: Amiri M, Khazaie H, Mohammadi M

Year: 2025 Feb 24

Category: Systematic Review, Experimental Medicine

Journal: Animal Model Exp Med

DOI: 10.1002/ame2.12552

URL: https://onlinelibrary.wiley.com/doi/10.1002/ame2.12552

Abstract

Overview

Due to the increasing prevalence of cell phone use, there is mounting concern about the adverse effects of electromagnetic radiation (EMR) on human health, specifically on neuropsychological and reproductive systems. Oxidative stress has been highlighted as the leading cause of these harmful effects. This systematic review aims to provide a comprehensive analysis of melatonin's protective role against cell phone-induced electromagnetic waves in various organs using animal models.

Methods

  • Systematic review conducted using data from multiple scholarly databases, including Google Scholar, PubMed, Embase, Scopus, Web of Science, and Science Direct.
  • Selected studies published in English, focusing on keywords: 'melatonin', 'cell phone radiation', and 'animal model'.
  • The PRISMA process and JBI checklist were utilized to ensure the quality and validity of included articles.

Findings

  • Out of the reviewed literature, 11 high-quality articles were analyzed in detail.
  • Focus was given to the effects of melatonin and electromagnetic waves on organs such as the brain, skin, eyes, testis, and kidneys.
  • Evidence shows that EMR enhances oxidative activity in these tissues, resulting in tissue atrophy and cell death.
  • Melatonin was found to significantly bolster the antioxidant system of cells, mitigating the damaging effects of EMR and protecting tissues.
  • The presence of melatonin greatly reduced tissue atrophy and cell death caused by electromagnetic radiation.

Conclusion

The review affirms a strong link between electromagnetic waves from cell phones and organ damage in animal models, highlighting the safety and efficacy of melatonin in combatting these harmful effects. The results underscore melatonin's potential as a pharmaceutical intervention for EMF-induced tissue damage, and recommend further research and clinical trials in humans to determine optimal dosing and timing.
It is crucial to advance our understanding of melatonin physiology in this context to maximize its therapeutic applications against EMF-related health complications.

melatonin electromagnetic waves cell phone radiation oxidative stress animal models organ protection tissue damage
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