DNA Damage Analysis in Blood Tissue & Physiopathological Evaluation of the Effect of Quercetin on Kidney Tissue in 2600 MHz EMF Exposure

Authors: Karaman IP, Coskun O, Senol N, Aslankoc R, Comlekci S

Year: 2025 Dec 16

Category: Toxicology, Physiology

Journal: Altern Ther Health Med

URL: https://pubmed.ncbi.nlm.nih.gov/41411134/

Abstract

Overview

Electrical devices surrounding us are sources of electromagnetic fields (EMF). The electromagnetic radiation (EMR) from these sources induces formation of free radicals, leading to oxidative damage in various tissues. The kidney is highly sensitive to this oxidative damage.

Study Aim

This study evaluated the physiopathological effects of 2600 MHz EMF exposure on the kidney tissue of rats and the resulting DNA damage in blood tissue. The antioxidant quercetin (Qu) was used to attempt to reduce these effects.

Methods

  • Male Wistar-Albino rats were split into four groups (8 rats per group):
    • Group 1: control
    • Group 2: sham
    • Group 3: EMF exposure
    • Group 4: EMF + quercetin (Qu)
  • After 30 days, kidney tissues were harvested for physiopathological examination.
  • Blood samples were analyzed for DNA damage using the Comet assay method.

Findings

  • Histopathology of kidney tissue revealed low-level tubular dilatation damage in all groups.
  • Immunohistochemical evaluation gave similar results across all groups.
  • No significant change in malondialdehyde, catalase, and superoxide dismutase levels was found.
  • Significantly, the EMF group exhibited observable DNA damage in lymphocytes (P = .007, <.05).

Conclusion

  • 2600 MHz EMF exposure did not cause severe or significant damage to kidney tissue.
  • However, EMF exposure notably caused DNA damage in blood tissue, highlighting a clear connection between EMF exposure and biological risk at the DNA level.
EMF DNA damage quercetin kidney tissue oxidative stress rat study comet assay
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