The effect of vitamin E and C on comet assay indices and apoptosis in power plant workers: A double blind randomized controlled clinical trial

Authors: Bagheri Hosseinabadi M, Khanjani N, Atashi A, Norouzi P, Mirbadie SR, Mirzaii M

Year: 2020 Feb - Mar

Category: Clinical Trial

Journal: Mutat Res

DOI: 10.1016/j.mrgentox.2020.503150

URL: https://www.ncbi.nlm.nih.gov/pubmed/32247559

Abstract

Overview

Extremely low frequency electromagnetic fields are recognized as a possible carcinogen. Concerns exist about the health effects on employees at thermal power plants who are exposed to these fields. This study evaluates the impact of vitamin E and C supplements on these workers.

Methodology

This double-blind randomized controlled clinical trial involved 81 power plant workers. Conducted from July to November 2017, participants were divided into four groups: one received vitamin E (400 units/day), the second vitamin C (1000 mg/day), the third a combination of both, and the fourth no supplements.

Findings

  • DNA damage measured through the comet assay showed a significant decrease in groups taking vitamin E alone or combined with vitamin C.
  • No significant changes were observed in comet assay indices in the control group.
  • Flow cytometry indices, including early and late apoptosis as well as necrosis, remained unchanged post-intervention across all groups.

Conclusion

The use of antioxidant vitamins like E and C might enhance the activity of the non-enzymatic antioxidant defense system and protect DNA from damage due to exposure to electromagnetic fields. However, these vitamins do not influence apoptosis rates. The consumption of vitamin E is highlighted as potentially the most effective intervention.

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