Effects of radiofrequency field exposure on proteotoxic-induced and heat-induced HSF1 response in live cells using the bioluminescence resonance energy transfer technique

Authors: Emmanuelle Poque, Hermanus J Ruigrok, Delia Arnaud-Cormos, Denis Habauzit, Yann Chappe et al.

Year: 2020 Oct 16

Category: Cell Biology

Journal: Cell Stress Chaperones

DOI: 10.1007/s12192-020-01172-3

URL: https://pubmed.ncbi.nlm.nih.gov/33067759/

Abstract

Overview

This study examines the effects of radiofrequency (RF) field exposure on Heat Shock Factor 1 (HSF1) trimerization in live cells, an essential part of the cellular stress response mechanism, using the innovative bioluminescence resonance energy transfer (BRET) technique.

Findings

  • Confirmed acute RF effects from high-level exposure (non-specific heating ≥ 1°C) pose potential health hazards.
  • Detailed examination of HSF1 activation under low-level RF signal exposure, evaluating Celsius Inclinometers (CW), Global System for Mobile Communications (GSM), and Wi-Fi-modulated 1800 MHz signals.
  • Acute exposure findings show heat activation of HSF1 in cells exposed to high RF levels but no HSF1 activation under fixed temperature conditions.
  • No evidence suggesting modifications in HSF1 response after chronic RF exposure (1.5 and 6 W/kg) over 24 hours, thereby questioning the proteotoxicity induced under these RF exposures.

      • Conclusion

      While the study reveals minimal effects of low-level RF exposure on HSF1 activity, the broader implications for environmental RF impacts on cellular mechanisms warrant further detailed study. Safety concerns regarding chronic RF exposure, especially at lower levels, remain a critical area of concern.

radiofrequency HSF1 activation health risks bioluminescence resonance energy transfer RF exposure proteotoxic stress
← Back to Stats