Histopathological, immunohistochemical, and stereological analysis of the effect of Gingko biloba (Egb761) on the hippocampus of rats exposed to long-term cellphone radiation
Abstract
Abstract Summary
Overview
Cellular phones emit electromagnetic radiation (EMR) capable of penetrating the human body, leading to notable health hazards. The prevalent use of mobile devices heightens concerns regarding the impacts of radiofrequency (RF) emissions on human health, particularly on brain regions like the hippocampus adjacent to cellphone usage areas.
Findings
- Examination of rat hippocampi after prolonged exposure to harmful cellphone EMR levels (0.96 W/kg SAR) was conducted for one month.
- The study focused on the detrimental effects of EMR exposure and explored potential mitigation with ginkgo biloba (Egb761).
- Results indicated increased levels of apoptotic proteins (Bax, Acas-3), reduced anti-apoptotic protein (Bcl-2) immunoreactivity, and lowered total granule and pyramidal cell counts in EMR exposed rats.
- Conversely, in rats treated with Egb761, there was a decrease in apoptotic markers, an increase in Bcl-2 immunoreactivity, reduction in TUNEL-stained apoptotic cells, and a higher overall viable cell count.
Conclusion
Chronic exposure to cellphone EMR adversely affects hippocampal cell viability. Administering Egb761 can mitigate some of these harmful effects, suggesting its potential for neuroprotective applications against cellphone radiation.