Abstract

Study Overview

The purpose of this research was to assess the impact of prolonged exposure to mobile phone radiation at 1800 MHz on immature male mice across different operational modes, including Dialing, Receiving, and Stand-by.

Methodology

The study involved the exposure of three-week-old male mice to mobile phone radiation for three hours per day over a period of 120 days. Various tests such as HE staining, ELISA, biochemical estimations, immunofluorescence, and Western blot were utilized to analyze changes in testicular function and cellular integrity.

Key Findings

• Significant reduction in the diameter of seminiferous tubules.
• Decrease in sperm count and viability.
• Increase in germ cell apoptosis.
• Drop in serum testosterone levels.
• Alterations in testicular redox status, characterized by increased levels of ROS, NO, and MDA, along with a decrease in antioxidant enzymes.
• Enhanced expression of pro-apoptotic and apoptotic proteins with reduced levels of anti-apoptotic proteins, leading to increased apoptotic activity among testicular cells.

Conclusion

The findings suggest that long-term exposure to 1800 MHz mobile phone radiation can induce severe oxidative stress resulting in significant damage to testicular cells and impaired testicular function, urging the need for greater awareness and regulatory measures to protect reproductive health against long-term mobile radiation exposure.