Modeling the interplay between myelin architecture and local electromagnetic fields

Authors: Han J, Qin P, Zhu G, Wang R, Bai S, Wen J, Italiano M, Aplin F, Lovell NH, Tsai D, Wang H, Guo T

Year: 2025 Jul

Category: Neuroscience

Journal: Annu Int Conf IEEE Eng Med Biol Soc

DOI: 10.1109/EMBC58623.2025.11253436

URL: https://ieeexplore.ieee.org/document/11253436

Abstract

Overview

Myelin plays a vital role in the functioning of the nervous system and is highly susceptible to damage in neurodegenerative diseases. This study investigates how alterations in electromagnetic fields associated with myelin can reflect its integrity.

  • Developed a 3D microstructure model using finite element analysis and high-resolution imaging
  • Simulated detailed electromagnetic field distributions, retaining key microstructural features

Findings

Key Results:

  • The myelin microstructure significantly influences the distribution of electromagnetic fields across neural tissues.
  • Variations in these fields could potentially serve as indicators of myelin health and integrity.
  • Combining assessments of both electric and magnetic fields enhances comprehensive understanding of myelin condition.

Conclusion

Clinical Relevance: This work provides a non-invasive framework for tracking disease progression by analyzing electromagnetic signatures. It offers new insights into mechanisms underlying neurodegenerative diseases and highlights the direct connection between local electromagnetic field variation and myelin integrity, supporting EMF safety evaluation in neurological contexts.

myelin electromagnetic fields neurodegenerative diseases microstructure modeling finite element analysis nervous system non-invasive diagnostics
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