Low-intensity EMFs induce human cryptochrome to modulate intracellular reactive oxygen species

Authors: Sherrard RM, Morellini N, Jourdan N, El-Esawi M, Arthaut LD, Niessner C, Rouyer F, Klarsfeld A, Doulazmi M, Witczak J, d'Harlingue A, Mariani J, Mclure I, Martino CF, Ahmad M

Year: 2018 Oct 2

Category: Biomedicine

Journal: PLoS Biology

Institution: PLoS Biol

DOI: 10.1371/journal.pbio.2006229

URL: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006229

Abstract

Abstract Summary

Overview

Exposure to man-made electromagnetic fields (EMFs), which increasingly pollute our environment, is a matter of ongoing concern and debate due to their potential health consequences.

Findings

  • Weak pulsed electromagnetic fields (PEMFs) lead to rapid accumulation of reactive oxygen species (ROS) in mammalian cells.
  • ROS plays a significant role in stress response and aging, and its increase can impede cell growth and activate genes responsive to ROS.
  • The response to weak EMFs requires cryptochrome, a magnetosensor that synthesizes ROS, suggesting a widespread, general response in living systems.
  • This process may explain both the therapeutic and pathological impacts of EMFs.

Conclusion

Stimulating ROS production through low-intensity magnetic fields has implications for developing non-invasive therapies, but also poses potential health risks with increased ROS levels.

Note: Understanding these mechanisms could optimize the use of magnetic fields in medical treatment while minimizing adverse effects.

EMFs human health reactive oxygen species cryptochrome magnetic fields cellular mechanisms therapeutic applications
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