2.4 GHz Electromagnetic Field Influences the Response of the Circadian Oscillator in the Colorectal Cancer Cell Line DLD1 to miR-34a-Mediated Regulation

Authors: Olejárová S, Moravčík R, Herichová I

Year: 2022 Oct 30

Category: Molecular Biology

Journal: Int J Mol Sci

DOI: 10.3390/ijms232113210

URL: https://www.mdpi.com/1422-0067/23/21/13210

Abstract

Overview

The study explores the impact of Radiofrequency Electromagnetic Fields (RF-EMF) on biological processes, particularly circadian rhythms, influenced by the non-coding RNA, miR-34a. This RNA plays a pivotal role in the regulation of genes linked to the circadian clock in the colorectal cancer cell line DLD1.

Findings

  • miR-34a adjustment of genes like per2 and bmal1, critical to the circadian oscillator, is modified under the influence of a 2.4 GHz RF-EMF.
  • Exposure results in altered cell behavior, diminishing the miR-34a-mediated suppression of proliferation and migration.
  • Specific enhancements in mRNA expressions, such as cry1, demonstrate significant modulation by RF-EMF.

Conclusion

The results underline the substantial effects of RF-EMF on cellular regulatory mechanisms mediated by miR-34a in DLD1 cells. These alterations suggest a shift in tumor-suppressive roles of certain genes under EMF exposure, aligning with WHO's classification of RF-EMF as a possible carcinogenic factor.

EMF circadian rhythms miR-34a cancer cell regulation gene expression oncogenic capacity
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