GSM-like radiofrequency exposure induces apoptosis via caspase-dependent pathway in infant rabbits

Authors: Meral O, Ozgur E, Kismali G, Guler G, Alpay M, Sel T, Seyhan N.

Year: 2016

Category: Biochemistry

Journal: Bratisl Lek Listy

Institution: Bratisl Lek Listy

DOI: 10.4149/BLL_2016_129

URL: https://www.ncbi.nlm.nih.gov/pubmed/28125894

Abstract

Abstract Summary

Overview

Given the increasing concerns about radiofrequency (RF) exposure's impact, particularly among vulnerable populations like infants, this research focuses on understanding how GSM-like RF exposure affects juvenile organisms. This study specifically investigates the apoptotic responses in infant rabbits following exposure to RF fields.

Objective

The primary aim of the study was to analyze the effect of RF fields on apoptotic factors in newborn rabbit liver tissues.

Materials and Methods

Measurement of Cytochrome c and Apoptosis Inducing Factor (AIF) levels via western blot.
Determination of caspase 1, 3, and 9 activities using a colorimetric method.

Findings

While Cytochrome c and AIF levels showed no change, there was a significant increase in caspase activities in female infant rabbits exposed to 1800 MHz GSM-like RF signals at 1 month of age. Conversely, male infant rabbits exposed during the gestational period showed a decrease in caspase 1 and 3 levels.

Conclusion

The findings suggest that postnatal RF exposure may lead to a caspase-dependent pathway of apoptosis in female infant rabbits' liver tissues. Such insights underscore the potential health risks associated with RF exposure in early developmental stages.

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