Random Effects in Magnetobiology and a Way to Summarize Them

Authors: Vladimir N Binhi

Year: 2021 Jul 7

Category: Bioelectromagnetics

Journal: Bioelectromagnetics

DOI: 10.1002/bem.22359

URL: https://pubmed.ncbi.nlm.nih.gov/34233018/

Abstract

Abstract Summary of "Random Effects in Magnetobiology and a Way to Summarize Them"

Overview

In the field of magnetobiology, the reproduction of biological effects attributed to weak magnetic fields is notably challenging. These effects are nonspecific, not linked to specialized receptors, and exhibit variability that suggests the presence of multiple underlying statistical populations.

Findings

  • The data displays not just variability around a mean but significant random components that vary between populations.
  • This heterogeneity leads to issues with data reproducibility and is generally overlooked in conventional statistical analyses.
  • Adoption of random-effect meta-analysis for absolute values helps address these heterogeneous characteristics.
  • An improved estimator with reduced bias based on the folded normal distribution is introduced, enhancing data analysis accuracy.

Conclusion

The improved method was applied in a study involving the Stroop test under hypomagnetic conditions with 40 subjects, revealing a significant, though small, meta-effect. This suggests potential implications for better statistical handling and interpretation in magnetobiological research.

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