Genetic susceptibility may modify the association between cell phone use and thyroid cancer: A population- based case-control study in Connecticut

Authors: Luo J, Li H, Deziel NC, Huang H, Zhao N, Ma S, Nie X, tUdelsman R, Zhang Y

Year: 2019

Category: Epidemiology

Journal: Environmental Research

DOI: 10.1016/j.envres.2019.109013

URL: https://www.sciencedirect.com/science/article/abs/pii/S0013935119308102

Abstract

Overview

Radiofrequency radiation (RFR) from cell phones is suspected to be carcinogenic. This study conducted in Connecticut between 2010 and 2011 investigates the implications of genetic susceptibility on the development of thyroid cancer due to cell phone usage.

Findings

  • The study includes 440 cases of thyroid cancer and 465 controls, with genotyping of 823 SNPs in 176 DNA genes.
  • Significant genotype-environment interactions were found, suggesting increased risks of thyroid cancer with certain genetic predispositions when combined with cell phone use.
  • An elevated risk was observed with specific SNPs like rs11070256 and rs1695147 among others, particularly in the presence of cell phone exposure.

Conclusion

The data reinforces potential carcinogenic classification of RFR and indicates that genetic backgrounds may intensify the risk of thyroid cancer associated with cell phone use.

thyroid cancer cell phone use genetic susceptibility radiofrequency radiation epidemiology
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