Abstract

Overview

Pulsed electromagnetic field (PEMF) therapy is recognized for its ability to interact with biological systems, impacting them through both interfering and coherent fields. This therapy is known to vary in its effects based on the type of cell, signal characteristics, and stimulus parameters.

Findings

• The study analyzed data collected from 92 published research articles between 1999 and 2019.
• Data extracted focused on human cell experiments, exposure frequencies, flux densities, and the resulting cellular responses.
• Observations indicate that among the human cell experiments conducted, only 51.05% demonstrated notable cellular changes.
• Among the more responsive cells were MG-63 human osteosarcoma cells and bone marrow mesenchymal stem cells, notably responsive to PEMFs.
• However, human osteogenic sarcoma SaOS-2 and human adipose-derived mesenchymal stem cells showed reduced sensitivity.
• Greater responses were seen with frequencies above 100 Hz, flux densities of 1-10 mT, and exposure durations exceeding 10 days.

Conclusion

This analysis underscores the significance of cell type and signal characteristics in PEMF therapies, contributing valuable insights for future in vitro and preclinical studies.