Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code

Abstract

Overview

We explore the intricate array of signals that dictate the formation of biological shapes and functionalities. This discussion spans multiple scales, from nanoarchitectures influenced by supramolecular interactions to complex anatomical developments.

Findings

• Physical forces play a pivotal role in cellular decision-making processes, with notable parallels in areas such as early morphogenesis, tissue regeneration, and oncogenic adaptation.
• Biological patterning is intricately tied to the vibrational aspects of physical energies that are universal. We interpret these energetic interplays in biological dynamics as a convergence of physics and chemistry.
• Nanomechanical movements and electromagnetic waves are described as a collective of vibrations acting as control mechanisms for molecular arrangements.
• The role of the cytoskeleton is emphasized as both a transmitter and recipient of physical signals, crucial in defining biological identity across cellular and organ levels.

Conclusion

The profound impact of physical energies on biological systems opens new avenues for non-invasive medical approaches such as in situ stem/somatic cell reprogramming and tissue regeneration without the need for stem cell transplants.