Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code

Abstract

Overview

We discuss emerging views on the signals that control biological shapes and functions, from the nanoarchitectonics arising out of supramolecular interactions to the cellular/multicellular tissue level and the development of complex anatomy.

Findings

This study highlights the fundamental role of physical forces in cellular decisions. It illustrates the intriguing similarities observed in early morphogenesis, tissue regeneration, and oncogenic drift. The research presents compelling evidence that biological patterns are intricately embedded within the vibrational nature of physical energies that envelop the universe. Moreover, biological dynamics are portrayed as informational processes where physics and chemistry converge, powered by nanomechanical motions, and electromagnetic waves, including light, which act as a control software for molecular patterning.

Biomolecular recognition is discussed in terms of coherent synchronizations among signaling entities, which are likened to oscillators converging to synchronize their vibrational modes. Furthermore, cytoskeletal elements are emerging as critical transmitters and receivers of physical signals, orchestrating biological identity from the cellular level to tissue/organ levels.

Conclusion

The paper outlines the potential of harnessing the diffusive properties of physical energies for in situ stem/somatic cell reprogramming and tissue regeneration without the need for stem cell transplantation.