Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats

Abstract

Overview

This study investigates the metabolic effects of a 15-minute exposure to a 60-Hz electromagnetic field (EMF) on fed or fasted male rats, focusing on hyperglycaemia and other metabolic and serum indicators.

Findings

• Exposure to a 60-Hz EMF increased blood glucose levels significantly in both fed and fasted rats.
• An attenuated second serum insulin peak was observed, along with decreases in free fatty acids and lactate levels.
• Increases in pyruvate and acetoacetate levels were also noted, indicating metabolic shifts.
• Influence on glucose metabolism was linked to the oxidized state of cellular redox environments and variations in insulin and glucagon secretion.
• Effects of the 60-Hz EMF were consistent even in animals previously subjected to chronic EMF exposure for 14 days.

Conclusion

The study highlighted significant metabolic disruptions and their correlation to the cellular redox state and hormonal changes due to a single short-term EMF exposure.