Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats

Abstract

Overview

The impact of exposure to extremely low-frequency electromagnetic fields (EMFs) on the endocrine system and cell proliferation is complex. Despite the known therapeutic benefits of specific uses, such as magneto-therapy, EMFs can also trigger adverse metabolic effects like hyperglycaemia.

Findings

• A study conducted on male rats, both fed and fasted, observed their metabolic responses after a single 15-minute exposure to a 60-Hz EMF at an intensity of 3.8 mT.
• This exposure resulted in hyperglycaemia in both groups and affected serum insulin and glucagon levels noticeably.
• Additionally, there were changes in levels of free fatty acids, lactate, pyruvate, and acetoacetate, highlighting alterations in cellular energy and redox states.
• Significant findings also noted were a more oxidized cellular redox state along with variations in insulin and glucagon secretion post EMF exposure.

Conclusion

The research indicates that even a single exposure to a 60-Hz EMF can have substantial effects on glucose metabolism and the insulin/glucagon ratio, influenced by the cellular redox state. The effects remained unchanged even in animals previously subjected to chronic EMF exposure.