On the magnetosensitivity of lipid peroxidation: two- versus three-radical dynamics

Authors: Sampson C, Keens RH, Kattnig DR

Year: 2019 Jun 26

Category: Chemical Physics

Journal: Phys Chem Chem Phys

DOI: 10.1039/c9cp01746a

URL: https://www.ncbi.nlm.nih.gov/pubmed/31210238

Abstract

Overview

We present a theoretical analysis of the putative magnetosensitivity of lipid peroxidation, focusing on recognized mechanisms and newly suggested ideas in this field.

Findings

  • The study examines the radical pair mechanism (RPM) and a novel suggestion based on three-radical dynamics due to mutual electron-electron dipolar coupling (D3M).
  • It challenges existing literature by showing non-zero hyperfine coupling interactions in lipid peroxides, indicating potential magnetosensitivity by RPM.
  • The D3M may produce larger magnetic field effects (MFE) than RPM, particularly effective in low-field situations similar to geomagnetic fields.
  • This is attributed to the resilience of D3M to large exchange coupling interactions, which could enhance MFE under specific radical concentrations.

Conclusion

Considering radical concentration, D3M could be significantly relevant for MFE, especially under conditions of oxidative stress, suggesting intricate dependence on biochemical environment conditions.

magnetosensitivity lipid peroxidation radical pair mechanism spin dynamics oxidative stress
← Back to Stats