Analysis of the metabolic profile of humans naturally exposed to RF-EM radiation

Authors: Rangesh NM, Malaisamy AK, Kumar N, Kumar S

Year: 2024 May 18

Category: Metabolomics, Environmental Health

Journal: Metabolomics

DOI: 10.1007/s11306-024-02121-2

URL: https://pubmed.ncbi.nlm.nih.gov/38762651/

Abstract

Overview

Wireless communication and connectivity have become pervasive in modern life, leading to steadily increasing exposure to radiofrequency-electromagnetic field (RF-EM) radiation from low-cost, low-power, and miniature devices. This environmental change has heightened concerns regarding potential effects on biological systems. Past studies are mixed, with inconsistent findings on the impact of RF-EM radiation.

Study Objectives

  • Two micro-environments were identified based on RF-EM exposure: one with high exposure and one with low exposure.
  • The study aimed to determine short-term metabolic dysregulations through analysis of urine metabolites from humans in these environments.

Methods

  • Applied untargeted 1H NMR spectroscopy for metabolomics analysis of urine samples.
  • 60 participants: 30 from a highly exposed group, 30 from a low-exposure group.

Findings

  • A total of 29 metabolites showed dysregulation: 19 downregulated and 10 upregulated.
  • Particularly affected were Glyoxylate and dicarboxylate, along with TCA cycle metabolism pathways.
  • Validation of dysregulated metabolites was performed using ROC curve analysis.

Conclusion

The analysis identified urinary metabolic changes associated with RF-EM radiation exposure, highlighting a potential link between oxidative stress, gut microbiota disturbance, and RF-EM exposure. These results suggest that individuals with lower radiation exposure demonstrated healthier metabolite profiles connected to gut microbiota. However, broader studies are required to validate these biomarkers and to clarify how RF-EM radiation may impact human health.

  • ⚠️ There appears to be a connection between RF-EM exposure, oxidative stress, and gut microbiota imbalance.
  • Further research is essential to confirm and expand upon these findings.
  • Future studies should include a more diverse population and control groups with minimal exposure.
RF-EM radiation metabolomics oxidative stress gut microbiota human exposure urine analysis NMR spectroscopy
← Back to Stats