Abstract

Overview

Fibromyalgia (FM) and Electromagnetic Sensitivity (IEI-EMF) represent chronic and systemic syndromes largely characterized by widespread musculoskeletal pain. The connection with electrical and electromagnetic devices which may trigger or amplify symptoms is particularly notable.

Findings

• Investigation involved analyzing the blood plasma metabolome of IEI-EMF and healthy subjects using 1H NMR spectroscopy combined with multivariate statistical analysis.
• No significant psychological or personality differences were found between IEI-EMF subjects and controls, including aspects like Locus of Control and anxiety.
• A distinct metabolic profile for IEI-EMF patients was identified, characterized by elevated levels of glycine and pyroglutamate, and reduced levels of 2-hydroxyisocaproate, choline, glutamine, and isoleucine.

Conclusion

The distinct metabolites identified are crucial in pathways related to oxidative stress defense, pain mechanisms, and muscle metabolism, suggesting potential physiopathological mechanisms in IEI-EMF patients that warrant further exploration and definition.