The cellular effects of Pulsed Electromagnetic Fields on osteoblasts: A review

Abstract

Overview

Electromagnetic fields (EMFs) have a history of interactions with biological organisms and have shown potential for therapeutic use. This review focuses on Pulsed Electromagnetic Fields (PEMFs) and their effects on osteoblasts, a critical area in bone healing processes.

Findings

• PEMFs have been tested in various in vitro osteoblast models, showing promising results for bone recovery and healing.
• The review highlights the mechanisms through which PEMFs influence cellular functions and the importance of parameters like frequency and intensity in clinical settings.
• Latest insights into cellular mechanisms such as primary cilia have been discussed, which might help explain the inconsistent results found in different studies.
• Two stimulation regimes which are most accredited and commonly used in clinical practices have been focused on, emphasizing the lack of systematic evidence and the need for more structured research.

Conclusion

The in-depth analysis of PEMFs reveals its significant impact on osteoblastic differentiation and the modulation of critical signaling pathways. However, to harness their full potential and ensure effective clinical applications, more targeted research is required to understand their cellular effects comprehensively.