The Effect of Pulsed Electromagnetic Fields on Angiogenesis

Abstract

Overview

Pulsed electromagnetic fields (PEMF) have been utilized in the treatment of several inflammation-based ailments including osteoporosis, neurological injuries, and osteoarthritis. This review delves into the impact of PEMF on angiogenesis—the process of new blood vessel formation, which is crucial for treating ischemic diseases.

Findings

• PEMF can potentially enhance angiogenesis, indicated by the increased rate of vascular growth and higher capillary density.
• Investigations reveal PEMF promotes crucial activities in vascular endothelial cells such as proliferation, migration, and tube formation.
• There is a significant impact on the expression levels of vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), and angiopoietin-2 (Ang-2).
• PEMF is noted for triggering the activation of voltage-gated calcium channels (VGCC), which plays a pivotal role in these processes.

Conclusion

The potential of PEMF in medical applications is vast, with a strong emphasis on promoting angiogenesis. This could translate into broader clinical uses beyond current treatments, highlighting the connection between electromagnetic fields and enhanced recovery in ischemic and other inflammation-related diseases.