Abstract

Overview

A pulsed electromagnetic field (PEMF) has been widely recognized for its therapeutic benefits, especially in treating inflammation-based diseases such as osteoporosis, neurological injuries, and osteoarthritis.

Findings

• Numerous animal experiments and in vitro studies indicate the potential of PEMF in influencing angiogenesis.
• The clinical applications of PEMF could extend well beyond current uses, particularly for ischemic diseases where enhanced angiogenesis can enrich blood flow to ischemic tissues.
• Specific PEMF parameters were found to promote angiogenesis, evident from increased vascular growth rates and capillary density.

Mechanisms Involved

PEMF's effectiveness in promoting angiogenesis includes:

• Enhancing vascular endothelial cell proliferation, migration, and tube formation.
• Increasing the expression of critical angiogenic growth factors such as VEGF, FGF2, and Ang-2.
• Impact on the activation of voltage-gated calcium channels (VGCC).

Conclusion

The reviewed evidence strongly supports the linkage of PEMF with enhanced angiogenesis, offering promising implications for its broader use in clinical settings.