Effect of cell-phone RF on angiogenesis and cell invasion in human head and neck cancer cells

Abstract

Overview

As cell-phone usage becomes increasingly widespread worldwide, concerns about its potential effects on health continue to rise. Specifically, the impact of cell-phone radiofrequency on cancer progression, especially in head and neck regions, has been understudied.

Methods

• The study utilized chorioallantoic membrane (CAM) and human cancer cell lines FaDu and SCC25 to investigate the effects on angiogenesis, cell invasion, and colony formation.
• Western blot analysis was performed to assess changes in E-cadherin and Erk1/Erk2 genes due to cell phone radiofrequency exposure.

Findings

The results provided significant observations:

• Radiofrequency from cell phones was found to promote angiogenesis in CAM.
• Increased cell invasion and colony formation in head and neck cancer cells accompanied by a loss of E-cadherin expression.
• Additionally, Activation of Erk1 and Erk2 was discovered as a result of exposure, indicating a potentially crucial pathway by which radiofrequency aids cancer progression.

Conclusion

This investigation underlines a dangerous link between cell-phone usage and accelerated cancer progression through angiogenesis and increased cell invasion facilitated by radiofrequency signals. Further attention and examination of these findings are essential for public health safety.