Abstract

Overview

As ultra-high-voltage (UHV) direct-current (DC) transmissions expand, concerns about the health impacts of static electric fields (SEF) near overhead UHV DC lines have increased.

Findings

• Study observed effects of 56.3 kV/m SEF on mouse spleens over 21 days.
• Significant increases were noted in malonic dialdehyde, superoxide dismutase, calcineurin, and nitric oxide synthase activities.
• Elevated levels of tumor necrosis factor-α and nuclear factor-κB mRNA expression were detected.
• Structural changes in splenic lymphocytes included separation of nucleus from nuclear membrane, loss of mitochondrial membrane, and mitochondrial cristae deficiencies.

Conclusion

The study deduces that SEF exposure could induce oxidative stress in the spleen by enhancing nitric oxide synthase activity. This stress may lead to significant cellular and molecular changes, contributing to the development of spleen inflammation.